KMID : 1024420140180040413
|
|
Food Engineering Progress 2014 Volume.18 No. 4 p.413 ~ p.418
|
|
Anti-obese and Antioxidant activities of Spica prunellae Extract in 3T3-L1 and HepG2 cells
|
|
Kim Nan-Seul
Shon Myung-Soo Kim Gyo-Nam Hwang Young-Il
|
|
Abstract
|
|
|
Spica prunellae has been used as a traditional medicine in Asian countries. In the present study, anti-obese and anti-oxidant activity of Prunellae spica ethanol extract (PSE) was investigated in 3T3-L1 and HepG2 cells. The 50 and100¥ìg/mL of PSE treatment for 4 days (Day -2 to Day 2) dose dependently suppressed 3T3-L1 adipogenesis. Wefurther examined the protective activity of PSE against ethanol-induced cell death. While 800mM ethanol treatmentfor 24 h induced significant cell death, the PSE treatment significantly protected ethanol-induced cell death. In addi-tion, the anti-oxidative activities of PSE to reduce the oxidative stress induced by AAPH or Cu2+ ions, which areimportant ROS to release peroxyl and hydroxyl radicals, were observed. These results provide scientific evidencefor the development of functional foods using PSE which has anti-obese and antioxidant activities.
|
|
KEYWORD
|
|
Spica prunellae, Oxidative Stress, Anti-obesity, Anti-oxidant
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|